Mechanism of BRG1 silencing in primary cancers
نویسندگان
چکیده
منابع مشابه
Mechanism of BRG1 silencing in primary cancers
BRG1 (SMARCA4) is a documented tumor suppressor and a key subunit of the SWI/SNF chromatin remodeling complex that is silenced in many cancer types. Studies have shown that BRG1 is mutated in cancer-derived cell lines, which led to the assertion that BRG1 is also mutated in primary human tumors. However, the sequencing of BRG1-deficient tumors has revealed a paucity of mutations; hence, the cau...
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A role for the SWI/SNF complex in tumorigenesis based on its requirement for retinoblastoma induced growth arrest and p53-mediated transcription and the appearance of tumors in SWI/SNF-deficient mice. In addition, Western blot data have shown that the SWI/SNF ATPase subunits cell, BRG1 and BRM (BRG1/BRM), are lost in approximately 30% of human non-small lung cancer cell lines. To determine whet...
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چکیده ندارد.
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(71) Applicants:Zainab JAGANI, Cambridge, MA (US); EPE" application No. 61/846,178, s s s Jul 15, 2013. Gregory HOFFMAN, Cambridge, MA ed. On Jul. 1, (US); Frank Peter STEGMEIER, Publication Classification Cambridge, MA (US); Craig Stephen MICKANIN, Cambridge, MA (US) (51) Int. Cl. CI2O I/68 (2006.01) (72) Inventors: Zainab JAGANI, Cambridge, MA (US); GOIN33/574 (2006.01) Gregory HOFFMAN, Cambr...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.10593